CONSORT-DEFINE EXPLANATION AND ELABORATION: RECOMMENDATIONS FOR ENHANCING REPORTING QUALITY AND IMPACT OF EARLY PHASE DOSE-FINDING CLINICAL TRIALSRESEARCH IN CONTEXT

Summary: Early phase dose-finding (EPDF) trials are key in the development of novel therapies, with their findings directly informing subsequent clinical development phases and providing valuable insights for reverse translation.Comprehensive and transparent reporting of these studies is critical for their accurate and critical interpretation, whic

BackgroundStudying prenatal influences of early life growth is relevant to life-course epidemiology as some of its features have been linked to the onset of later diseases.MethodsWe studied the association between prenatal maternal characteristics (height, age, parity, education, pre-pregnancy body mass index (BMI), smoking, cocktail tree for sale

Anopheles mosquitoes have transmitted Plasmodium parasites for millions of years, yet it remains unclear whether they suffer fitness costs to infection.Here we report that the fecundity of virgin and mated females of two important vectors-Anopheles gambiae and Anopheles stephensi-is not affected by infection with Plasmodium falciparum, demonstratin

Objectives Nonsurgical rhinoplasty using threads has gained popularity in recent years.While the benefits of this procedure have been emphasized, possible complications and their management are not well-known.This study aimed to present the surgical management and results of the complications of thread rhinoplasty.Methods We retrospectively reviewe